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KMID : 0438219720090020103
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Korea University Medical Journal
1972 Volume.9 No. 2 p.103 ~ p.111
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^(131)Ⅰ Distribution and Plasma Protein Fractionation in Hyper-and Hypo-thyroidism Rats
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Abstract
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Distribution of (131)^I between tissue and serum (T/S ratio), protein bound iodine and serum (PBI/S) were observed in 38 rats in which the function of thyroid gland was made hyperfunctional or hypofunctional. Hyperthyroid condition was made in 11 rats by the administration of thyroxine (1.7mg/kg /day) for over 21 days, in 12 rats hyporhyroid state was made by feeding a chow containing 0.1 % of propylthiouracil (PTU) for over 21 days. T/S ratio, PBI/S ratio of (131)^I were observed after 10, 20, 40, 80 and 120 minutes of peritoneal injection of 30μC Na (131)^1. Fractionation of plasma protein, relationship between the function of thyroid and body weight change, and ratio of thyroid weight and body weight were observed. The following results were obtained.
1. T/S ratio of (131)^I in normal rats (15 cases) was between 4.55 and 6.08, between 23.23 and 30.85 in thyroxine administered rats (11 cases), and between 7.18 and 14.34 in PTU administered rats. The variation of T/S ratio in time sequence was unremarkable.
2. PBI/S ratio of (131)^I was lowest in thyroxine administered rats, namely, it ranged between 7.36 and 9.74. In normal and PTU administered rats, the ratio was between 33.89 and 48.51, and between 32.51 and 42. 01, respectively.
3. In plasma protein of thyroxine administered rats β-globulin increased and γ-globulin decreased. In plasma protein of PTU administered rats there were increases in a₁ and γ-globulin. A/G ratio were 1.29 in normal rats, 1.22 in thyroxine administered rats and 1.10 in PTU administered rats, respectively.
4. Percent increase in body weight after 21 days of administration of thyroxine or feeding of PTU was smallest in the PTU administered rats, namely, 18.1%. Percent increase in body weight in normal rats was 26.0% and 22.1% in thyroxine administered rats.
5. The ratio of thyroid weight to body weight was highest in the PTU administered rats, namely, 0.22%. The ratio in normal rats was 0.19% and 0.20% in thyroxine administered rats.
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